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Ebola​-​induced intracellular hell (cytokine storm)

from For the sake of reproducibility - a technical replicate by Tumor Necrosis Factor-alpha

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lyrics

Abnormal immune response, suppression of adaptive immunity
Hypersecretion of cytokines, chemokines and growth factors, all proinflammatory
An observed lack of CD peripheral cells and T-lymphocytes showing low circulating cytokine production
In conjunction with the absence of IFNa2 increase, disrupting the innate immune reaction

cytokine storm - with a significant drop of CD peripheral cells
cytokine storm - EBOLA-induced intracellular hell

Defective early inflammatory responses and lymphocytic apoptosis
DNA fragmentation in peripheral blood cells, reduced interferon levels and necrosis
Drastically lower levels in lymphocytic populations were observed in fatally infected patients
Extremely high levels of circulating inflammatory molecules, dendritic cells' functional impairment

cytokine storm - with a significant loss of T-lymphocyte cells
cytokine storm - EBOLA-induced intracellular hell

Endothelial permeabilization, massive hemorrhagic manifestations
General immune system failure during the acute phase of infection

cytokine storm - with a significant drop of CD peripheral cells
cytokine storm - EBOLA-induced intracellular hell
cytokine storm - with a significant loss of T-lymphocyte cells
cytokine storm - EBOLA-induced intracellular hell

Ref: Paessler S, Walker DH “Pathogenesis of the viral hemorrhagic fevers.” Annual Review of Pathology: Mechanisms of Disease Vol. 8: 411-440 (2013)

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from For the sake of reproducibility - a technical replicate, released January 24, 2018

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Scientists, academics, gorefiends and grindheads of the world rejoice: Tumor Necrosis Factor-alpha unleashes its take on full blown Carcass-worship, topped with unique lyrical themes inspired by the most recent knowledge in state-of-the-art scientific research from the fields of cellular and molecular biology. ... more

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