Immunogenic cell death inducers: adaptive immune response against dead cell-associated antigens

from For the sake of reproducibility - a technical replicate by Tumor Necrosis Factor-alpha

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Immunodeficient murine animal models and cultured human cancer cells both serve as test subjects
in the screening of anticancer effects for various chemical compounds resulting in the identification of novel ICD inducers

Immunogenic cell death inducers, cytotoxic agents eliciting such manifestations as the release of HMGB1
other molecular changes include exposure of calreticulin at the cellular surface and lymphosomal ATP secretion

cytotoxic activity - toxicological evaluation
anticancer effects - in human neoplasms

A once compromised immune system by pharmacological intervention
Now sees its antineoplasic agents optimised by anticancer immunosurveillance re-activation
Adaptive immune response against dead cell-associated antigens
Harnessing the cell death signature, triggering ICD apoptotic stimulation

Ref: Sukkurwala AQ et al. “Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set.” OncoImmunology Vol. 3, Iss.4 (2014)

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from For the sake of reproducibility - a technical replicate, released January 24, 2018

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Tumor Necrosis Factor-alpha Neuville, Québec

Scientists, academics, gorefiends and grindheads of the world rejoice: Tumor Necrosis Factor-alpha unleashes its take on full blown Carcass-worship, topped with unique lyrical themes inspired by the most recent knowledge in state-of-the-art scientific research from the fields of cellular and molecular biology. ... more

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