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On the multiple conflicting roles of TNF in various debilitating conditions

from For the sake of reproducibility - a technical replicate by Tumor Necrosis Factor-alpha

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Infectious conditions and inflammation displaying a high serum level
Of an endotoxin-induced glycoprotein, the tumor necrosis factor
Found in T & B lymphocytes and natural killer cells
Transduction pathway still not understood fully well

Expressed on the membrane surface, cleaved by proteinases, released in a soluble form
Haemorrhagic necrosis of transplanted sarcomas evidence of pro-inflammatory response
Macrophages, neutrophils and endothelial cells
Cellular necrosis and tissular swelling
A defense against viral or parasitic infections
Turned harmful for the host when in excessive production

Once a glimmer of hope as a chemotherapeutic agent
Contradicted by several cases of metastatic invasion

In direct association with many inflammatory conditions, the tumor necrosis factor

Ref: Bradley JR “TNF-mediated inflammatory disease”. J Pathol 214: 149-160 (2008)

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Tumor Necrosis Factor-alpha Neuville, Québec

Scientists, academics, gorefiends and grindheads of the world rejoice: Tumor Necrosis Factor-alpha unleashes its take on full blown Carcass-worship, topped with unique lyrical themes inspired by the most recent knowledge in state-of-the-art scientific research from the fields of cellular and molecular biology. ... more

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